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Article

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.

Human molecular genetics - 1 Feb 2012

Colas Julien, Faure Grazyna, Saussereau Emilie, Trudel Stéphanie, Rabeh Wael M, Bitam Sara, Guerrera Ida Chiara, Fritsch Janine, Sermet-Gaudelus Isabelle, Davezac Noëlie, Brouillard Franck, Lukacs Gergely L, Herrmann Harald, Ollero Mario, Edelman Aleksander

Abstract excerpt

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum,...

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Source

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Identifiers

PMID: 22038833
DOI: 10.1093/hmg/ddr496
PMCID: PMC3259015

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22038833-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.PMID 22038833Read ↗

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