Article
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3.
Brain : a journal of neurology - 1 Apr 2006
Vance Caroline, Al-Chalabi Ammar, Ruddy Deborah, Smith Bradley N, Hu Xun, Sreedharan Jemeen, Siddique Teepu, Schelhaas H Jurgen, Kusters Benno, Troost Dirk, Baas Frank, de Jong Vianney, Shaw Christopher E
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are both relentlessly progressive and ultimately fatal neurological disorders. ALS is familial in approximately 10% of cases and FTD in approximately 30%. Inheritance is usually autosomal dominant with variable penetrance. Phenotypic overlap between ALS and FTD can occur within the same kindred. Mutations in copper/zinc superoxide dismutase 1...
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