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Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Archives of neurology - 1 May 2010

Gijselinck Ilse, Engelborghs Sebastiaan, Maes Githa, Cuijt Ivy, Peeters Karin, Mattheijssens Maria, Joris Geert, Cras Patrick, Martin Jean-Jacques, De Deyn Peter P, Kumar-Singh Samir, Van Broeckhoven Christine, Cruts Marc

Abstract excerpt

BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a neurodegenerative brain disorder that can be accompanied by signs of amyotrophic lateral sclerosis (ALS). OBJECTIVE: To identify a novel gene for FTLD-ALS. DESIGN: Genome-wide linkage study in a multiplex family with FTLD-ALS with subsequent fine mapping and mutation analyses. SETTING: Memory Clinic of the Middelheim General Hospital. PATIENTS: An extended...

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PMID: 20457961
DOI: 10.1001/archneurol.2010.82

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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