Article
Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p.
Journal of neurology - 1 Apr 2011
Pearson Justin P, Williams Nigel M, Majounie Elisa, Waite Adrian, Stott Jennifer, Newsway Victoria, Murray Alex, Hernandez Dena, Guerreiro Rita, Singleton Andrew B, Neal James, Morris Huw R
Abstract excerpt
Families with autosomal dominant frontotemporal dementia and amyotrophic lateral sclerosis (FTD/ALS) have previously been linked to a locus on chromosome 9p21. We describe the clinical phenotype and pathology of a large family with autosomal dominant FTD/ALS with nine affected members originating from Gwent in South Wales, UK. We also further refine the locus on chromosome 9p21 using a haplotype sharing approach...
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