Article
Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males.
Journal of the American Society of Nephrology : JASN - 1 Mar 2006
Doi Kent, Noiri Eisei, Nakao Akihide, Fujita Toshiro, Kobayashi Shuzo, Tokunaga Katsushi
Abstract excerpt
This study elucidates the genetic role of vascular endothelial growth factor (VEGF) as a predisposing factor for progression of chronic kidney disease. Single-nucleotide polymorphisms were genotyped and haplotype structures were determined in the 3' untranslated region (UTR) of VEGF gene, and the distribution of each haplotype in male patients with ESRD (n=101) and healthy male control subjects (n=189) was...
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