Article
Associations of single nucleotide polymorphisms in the vascular endothelial growth factor gene with the characteristics and prognosis of renal cell carcinomas.
European urology - 1 Oct 2007
Kawai Yoshihisa, Sakano Shigeru, Korenaga Yoshihito, Eguchi Satoshi, Naito Katsusuke
Abstract excerpt
OBJECTIVES: Vascular endothelial growth factor (VEGF) is considered to play critical roles in tumor development and progression, especially in renal cell carcinoma (RCC) via von Hippel-Lindau gene inactivation. Although VEGF -2578CC, -1154GG, and -634CC genotypes are reportedly correlated with higher levels of VEGF production, no previous studies have reported on the associations of these polymorphisms with RCCs....
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