Article
Association of the PIG3 promoter polymorphism with invasive bladder cancer in a Japanese population.
Japanese journal of clinical oncology - 1 Feb 2006
Ito Masaaki, Nishiyama Hiroyuki, Watanabe Jun, Kawanishi Hiroaki, Takahashi Takeshi, Kamoto Toshiyuki, Habuchi Tomonori, Ogawa Osamu
Abstract excerpt
PIG3 (p53-induced gene 3) is one of the targets of TP53 and is involved in apoptosis. The promoter of PIG3 contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n (Y = C or T) and the number of VNTRs was reported to be correlated with the activation by TP53. In this study, the clinical significance of the PIG3 promoter VNTRs was analyzed in the bladder cancer patients using the genome...
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