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Cigarette smoking combines with genetic variants to regulate FOXN3 and associate with bladder cancer risk.

Archives of toxicology - 1 Mar 2026

Zheng Yiwen, Wu Youhan, Zhang Jinyue, Zhao Chenfei, Wang Tianqin, Wang Qunbo, Lv Qiang, Qin Chao, Yuan Lin, Chu Haiyan, Du Mulong, Wang Meilin, Gu Jingjing, Liu Hanting

Abstract excerpt

FOXN family genes (FOXNs) have a significant role in the progression of various malignancies; nevertheless, the relationship between their genetic variations and the risk of bladder cancer is yet insufficiently comprehended. This study included 580 bladder cancer patients and 1,101 healthy controls, evaluated for 8,695 single nucleotide polymorphisms (SNPs) in FOXNs. The rs10484024 T > C variant in FOXN3 was...

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Aged
Case-Control Studies
Cigarette Smoking
Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 41361116
DOI: 10.1007/s00204-025-04244-4

Genes

FOXN3
KMT2C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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