Article
Brain and retinal ferroportin 1 dysregulation in polycythaemia mice.
Brain research - 15 Sept 2009
Iacovelli Jared, Mlodnicka Agnieska E, Veldman Peter, Ying Gui-Shuang, Dunaief Joshua L, Schumacher Armin
Abstract excerpt
Disruption of iron homeostasis within the central nervous system (CNS) can lead to profound abnormalities during both development and aging in mammals. The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptiona...
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