Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.

Epilepsia - 1 Jan 2006

Tupal Srinivasan, Faingold Carl L

Abstract excerpt

PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is a serious concern for epilepsy patients. DBA/2 mice are proposed as a SUDEP model, because these mice exhibit respiratory arrest (RA) after audiogenic seizures (AGSs), and RA is also implicated in human SUDEP. Respiratory mechanisms are modulated, in part, by serotonin. Therefore we evaluated the effects of serotoninergic agents on RA incidence in DBA/2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Death, Sudden
Share to Dose-Response Relationship, Drug
Share to Epilepsy, Reflex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluoxetine

Share to Mice, Inbred DBA

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin

Share to Serotonin Antagonists

Source

Identifiers

PMID: 16417527
DOI: 10.1111/j.1528-1167.2006.00365.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.PMID 16417527Read ↗

Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats.Semantic proximity Read ↗

Sudden unexpected death in epilepsy: ongoing challenges in finding mechanisms and prevention.Semantic proximity Read ↗

Effects of 5-HT receptor antagonists on seizure susceptibility and locomotor activity in DBA/2 mice.Semantic proximity Read ↗

Oxygenation prevents sudden death in seizure-prone mice.Semantic proximity Read ↗

Post-ictal generalized EEG suppression and seizure-induced mortality are reduced by enhancing dorsal raphe serotonergic neurotransmissionSemantic proximity Read ↗

Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs.Semantic proximity Read ↗

The Crucial Interplay Between the Lungs, Brain, and the Heart to Understand Epilepsy Linked SUDEP: A Literature ReviewSemantic proximity Read ↗

Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthoodSemantic proximity Read ↗

Mechanisms of sudden unexplained death in epilepsy.Semantic proximity Read ↗

X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsySemantic proximity Read ↗

Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.Semantic proximity Read ↗

Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.