Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.

doi:10.1111/j.1528-1167.2006.00365.x

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Article

Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.

Epilepsia - 1 Jan 2006

Tupal Srinivasan, Faingold Carl L

Abstract excerpt

PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is a serious concern for epilepsy patients. DBA/2 mice are proposed as a SUDEP model, because these mice exhibit respiratory arrest (RA) after audiogenic seizures (AGSs), and RA is also implicated in human SUDEP. Respiratory mechanisms are modulated, in part, by serotonin. Therefore we evaluated the effects of serotoninergic agents on RA incidence in DBA/2...

Topics

Animals
Cyproheptadine
Death, Sudden
Disease Models, Animal
Dose-Response Relationship, Drug
Epilepsy, Reflex
Fluoxetine
Genetic Predisposition to Disease
Humans
Mice
Mice, Inbred DBA
Respiratory Paralysis
Serotonin
Serotonin Agents
Serotonin Antagonists
Selective Serotonin Reuptake Inhibitors

Source

Open in PubMed

Identifiers

PMID: 16417527
DOI: 10.1111/j.1528-1167.2006.00365.x

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