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The Cell Killing Mechanisms of Hydroxyurea

17 Nov 2016

Abstract excerpt

Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long history of scientific interest and clinical use for the treatment of neoplastic and non-neoplastic diseases. It is currently the staple drug for the management of sickle cell anemia and chronic myeloproliferative disorders. Due to its reversible inhibitory effect on DNA replication in various organisms, hydroxyurea is also...

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PMID: 27869662
DOI: 10.3390/genes7110099

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