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Article

Biliverdin Rescues the HO-2 Null Mouse Phenotype of Unresolved Chronic Inflammation Following Corneal Epithelial Injury.

Investigative ophthalmology & visual science - 17 May 2011

Bellner Lars, Wolstein Jesse, Patil Kiran A, Dunn Michael W, Laniado-Schwartzman Michal

Abstract excerpt

PURPOSE. The heme oxygenase system (HO-1 and HO-2) represents an intrinsic cytoprotective and anti-inflammatory pathway based on its ability to modulate leukocyte migration and to inhibit the expression of inflammatory cytokines and proteins by its products biliverdin/bilirubin and carbon monoxide. Corneal injury in HO-2 null mice leads to impaired healing and chronic inflammatory complications, including...

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Source

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Identifiers

PMID: 21345995
DOI: 10.1167/iovs.10-6219
PMCID: PMC3109026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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