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Article

Stable Growth of Wild-Type Hepatitis A Virus in Cell Culture

13 Jan 2006

Abstract excerpt

Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable...

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PMID: 16415012
DOI: 10.1128/jvi.80.3.1352-1360.2006

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