Article
Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.
Psychiatry research - 28 Feb 2006
Shinkai Takahiro, Müller Daniel J, De Luca Vincenzo, Shaikh Sajid, Matsumoto Chima, Hwang Rudi, King Nicole, Trakalo Joseph, Potapova Natalia, Zai Gwyneth, Hori Hiroko, Ohmori Osamu, Meltzer Herbert Y, Nakamura Jun, Kennedy James L
Abstract excerpt
A possible involvement of oxidative stress in the pathophysiology of tardive dyskinesia (TD) has previously been proposed (reviewed in [Andreassen, O.A., Jorgensen, H.A., 2000. Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? Progress in Neurobiology 61, 525-541.]). Long-term administration of neuroleptics alters dopaminergic turnover, which results...
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