Article
Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Feb 2010
Zai Clement C, Tiwari Arun K, Basile Vincenzo, de Luca Vincenzo, Müller Daniel J, Voineskos Aristotle N, Remington Gary, Meltzer Herbert Y, Lieberman Jeffrey A, Potkin Steven G, Kennedy James L
Abstract excerpt
INTRODUCTION: Tardive dyskinesia (TD) is a potentially irreversible side effect of antipsychotic medication treatment that occurs in approximately 25% of chronically treated schizophrenia patients. Oxidative stress has been one of the proposed mechanisms influencing TD risk. Pae et al. (2004) originally reported a significant association between TD and the NADPH quinine oxidoreductase 1 (NQO1) gene Pro187Ser...
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