Article
No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia.
Psychiatric genetics - 1 Sept 2004
Shinkai Takahiro, De Luca Vincenzo, Zai Gwyneth, Shaikh Sajid, Matsumoto Chima, Arnold Paul D, Hwang Rudi, King Nicole, Trakalo Joseph, Potapova Natalia, Wong Gregory, Hori Hiroko, Wong Albert H C, Ohmori Osamu, Nakamura Jun, Kennedy James L
Abstract excerpt
OBJECTIVE: Oxidative stress such as free radical-mediated neuronal dysfunction may be involved in the pathophysiology of schizophrenia. The human glutathione peroxidase (GPX1) is a selenium-dependent enzyme, which plays an important role in the detoxification of free radicals. We therefore hypothesized that the GPX1 gene, which is located on chromosome 3p21.3, may be involved in the pathophysiology of...
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