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Article

Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations.

American journal of epidemiology - 15 Feb 2006

Trikalinos Thomas A, Salanti Georgia, Khoury Muin J, Ioannidis John P A

Abstract excerpt

The authors evaluated whether statistically significant violations of Hardy-Weinberg equilibrium (HWE) or the magnitude of deviations from HWE may contribute to the problem of replicating postulated gene-disease associations across different studies. Forty-two gene-disease associations assessed in meta-analyses of 591 studies were examined. Studies with disease-free controls in which HWE was violated gave...

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Source

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PMID: 16410351
DOI: 10.1093/aje/kwj046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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