Article
How should we use information about HWE in the meta-analyses of genetic association studies?
International journal of epidemiology - 1 Feb 2008
Minelli Cosetta, Thompson John R, Abrams Keith R, Thakkinstian Ammarin, Attia John
Abstract excerpt
BACKGROUND: It is often recommended that control groups in meta-analyses of genetic association studies are checked for Hardy-Weinberg equilibrium (HWE) as a surrogate for assessing study quality. However, tests for HWE have low power and there is currently no consensus about how to handle studies that deviate significantly from HWE. METHODS: We identified 72 papers describing 114 meta-analyses of 1603 primary...
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