Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

15 Apr 2000

Abstract excerpt

In the genetic disease cystic fibrosis, recombinant adeno-associated virus type 2 (AAV2) is being investigated as a vector to transfer CFTR cDNA to airway epithelia. However, earlier work has shown that the apical surface of human airway epithelia is resistant to infection by AAV2, presumably as a result of a lack of heparan sulfate proteoglycans on the apical surface. This inefficiency can be overcome by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Respiratory viral infections research
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10729159
DOI: 10.1128/jvi.74.8.3852-3858.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene TransferPMID 10729159Read ↗

Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant Adeno-Associated Virus TransductionSemantic proximity Read ↗

Adeno-Associated Virus Types 5 and 6 Use Distinct Receptors for Cell EntrySemantic proximity Read ↗

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.Semantic proximity Read ↗

Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction propertiesSemantic proximity Read ↗

Adeno-Associated Virus Type 6 (AAV6) Vectors Mediate Efficient Transduction of Airway Epithelial Cells in Mouse Lungs Compared to That of AAV2 VectorsSemantic proximity Read ↗

Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministeredSemantic proximity Read ↗

Factors Influencing Adeno-Associated Virus-Mediated Gene Transfer to Human Cystic Fibrosis Airway Epithelial Cells: Comparison with Adenovirus VectorsSemantic proximity Read ↗

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene TherapySemantic proximity Read ↗

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoidsSemantic proximity Read ↗

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway EpitheliumSemantic proximity Read ↗

Identification of host essential factors for recombinant AAV transduction of the polarized human airway epitheliumSemantic proximity Read ↗

Transduction Efficiencies of Novel AAV Vectors in Mouse Airway Epithelium In Vivo and Human Ciliated Airway Epithelium In VitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.