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Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes

1 Feb 2000

Abstract excerpt

Vectors derived from adeno-associated virus type 2 (AAV2) promote gene transfer and expression in the lung; however, we have found that while gene expression can persist for at least 8 months in mice, it was reduced dramatically in rabbits over a period of 2 months. The efficiency and persistence of AAV2-mediated gene expression in the human lung have yet to be determined, but it seems likely that...

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PMID: 10627564
DOI: 10.1128/jvi.74.3.1524-1532.2000

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