Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes.

doi:10.1128/MCB.15.3.1709

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Article

Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes.

Molecular and cellular biology - 1 Mar 1995

Ashburner B P, Lopes J M

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the phospholipid biosynthetic genes are highly regulated at the transcriptional level in response to the phospholipid precursors inositol and choline. In the absence of inositol and choline (derepressing), the products of the INO2 and INO4 genes form a heter...

Topics

Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Chloramphenicol O-Acetyltransferase
Chromosomes, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Regulator
Genotype
Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeostasis

Kinetics

Molecular Sequence Data

Phospholipids

Promoter Regions, Genetic

Recombinant Proteins

Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7862162
DOI: 10.1128/MCB.15.3.1709
PMCID: PMC230395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7862162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes.PMID 7862162Read ↗

Expression of the INO2 regulatory gene of Saccharomyces cerevisiae is controlled by positive and negative promoter elements and an upstream open reading frame.Semantic proximity Read ↗

Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms.Semantic proximity Read ↗

Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p.Semantic proximity Read ↗

Identification of novel dominant INO2c mutants with an Opi- phenotype.Semantic proximity Read ↗

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the yeast VAP homolog, Scs2p, in INO1 expression and phospholipid metabolism.Semantic proximity Read ↗

Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol.Semantic proximity Read ↗

Over-expression of the INO2 regulatory gene alters regulation of an INO1-lacZ reporter gene but does not affect regulation of INO1 expression.Semantic proximity Read ↗

The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast.Semantic proximity Read ↗

Opi1 mediates repression of phospholipid biosynthesis by phosphate limitation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Opi1p, Ume6p and Sin3p control expression from the promoter of the INO2 regulatory gene via a novel regulatory cascade.Semantic proximity Read ↗

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