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Article

The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases.

The Journal of biological chemistry - 16 Aug 2013

Bar-Rogovsky Hagit, Hugenmatter Adrian, Tawfik Dan S

Abstract excerpt

Serum paraoxonases (PONs) are detoxifying lactonases that were first identified in mammals. Three mammalian families are known, PON1, 2, and 3 that reside primarily in the liver. They catalyze essentially the same reaction, lactone hydrolysis, but differ in their substrate specificity. Although s...

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Source

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Identifiers

PMID: 23788644
DOI: 10.1074/jbc.M112.427922
PMCID: PMC3745338

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23788644-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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