Article
The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides.
Bioscience, biotechnology, and biochemistry - 1 Feb 2009
Ohashi Takao, Ikeda Yuka, Tanaka Naotaka, Nakakita Shin-ichi, Natsuka Shunji, Giga-Hama Yuko, Takegawa Kaoru
Abstract excerpt
Unlike the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe synthesizes large outer chains on the N-linked oligosaccharides that consist mainly of D-Gal and D-Man residues. The fission yeast och1(+) gene product has alpha1,6-mannosyltransferase activity, and Och1p is the key enzyme in the initiation of outer chain elongation. Although the in vitro substrate specificity of S....
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