Article
Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel.
The Journal of biological chemistry - 24 Mar 2006
Beahm Derek L, Oshima Atsunori, Gaietta Guido M, Hand Galen M, Smock Amy E, Zucker Shoshanna N, Toloue Masoud M, Chandrasekhar Anjana, Nicholson Bruce J, Sosinsky Gina E
Abstract excerpt
Single site mutations in connexins have provided insights about the influence specific amino acids have on gap junction synthesis, assembly, trafficking, and functionality. We have discovered a single point mutation that eliminates functionality without interfering with gap junction formation. The mutation occurs at a threonine residue located near the cytoplasmic end of the third transmembrane helix. This...
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