Article
Cytomembrane Trafficking Pathways of Connexin 26, 30, and 43.
International journal of molecular sciences - 19 Jun 2023
Zong Yan-Jun, Liu Xiao-Zhou, Tu Lei, Sun Yu
Abstract excerpt
The connexin gene family is the most prevalent gene that contributes to hearing loss. Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly expressed connexins in the inner ear. Connexin 43, which is encoded by GJA1, appears to be widely expressed in various organs, including the heart, skin, the brain, and the inner ear. The mutations that arise in GJB2, GJB6, and GJA1 can all...
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