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Article

Rare expression of KIT and absence of KIT mutations in high grade renal cell carcinoma.

The Journal of urology - 1 Jan 2006

Sengupta Shomik, Cheville John C, Corless Christopher L, Lohse Christine M, Heinrich Michael C, Kwon Eugene D, Zincke Horst, Blute Michael L, Leibovich Bradley C

Abstract excerpt

PURPOSE: RCCs with sarcomatoid differentiation have been reported to frequently express KIT protein, suggesting that imatinib mesylate (STI-571 or Gleevectrade mark) may be effective treatment for these aggressive tumors. We determined the frequency of KIT expression and mutation in a large series of high grade RCCs. MATERIALS AND METHODS: We identified 194 patients who underwent nephrectomy for unilateral,...

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Topics

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Share to Carcinoma, Renal Cell
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 16406868
DOI: 10.1016/S0022-5347(05)00059-5

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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