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Article

KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2004

Simon Ronald, Panussis Soti, Maurer Robert, Spichtin Hanspeter, Glatz Kathrin, Tapia Coya, Mirlacher Martina, Rufle Alex, Torhorst Joachim, Sauter Guido

Abstract excerpt

PURPOSE: KIT (CD117) is a transmembrane tyrosine kinase representing a target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations. EXPERIMENTAL DESIGN: To investigate the epidemiology of KIT overexpression and mutations, we investigated a series of 1654 breast cancers. All tumors were analyzed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14734467
DOI: 10.1158/1078-0432.ccr-0597-3

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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