Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features.

doi:10.1038/modpathol.2012.61

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Article

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2012

Chang Daniel T, Pai Rish K, Rybicki Lisa A, Dimaio Michael A, Limaye Maneesha, Jayachandran Priya, Koong Albert C, Kunz Pamela A, Fisher George A, Ford James M, Welton Mark, Shelton Andrew, Ma Lisa, Arber Daniel A, Pai Reetesh K

Abstract excerpt

Recent literature suggests an increasing incidence of colorectal carcinoma in young patients. We performed a histologic, molecular, and immunophenotypic analysis of patients with sporadic early-onset (≤40 years of age) colorectal carcinoma seen at our institution from the years 2000-2010 and compared these tumors to a cohort of consecutively resected colorectal carcinomas seen in patients >40 years of age. A...

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PMID: 22481281
DOI: 10.1038/modpathol.2012.61

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