Article
A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans.
American journal of human genetics - 1 Mar 2006
Puppala Sobha, Dodd Gerald D, Fowler Sharon, Arya Rector, Schneider Jennifer, Farook Vidya S, Granato Richard, Dyer Thomas D, Almasy Laura, Jenkinson Christopher P, Diehl Andrew K, Stern Michael P, Blangero John, Duggirala Ravindranath
Abstract excerpt
Gallbladder disease (GBD) is one of the major digestive diseases. Its risk factors include age, sex, obesity, type 2 diabetes, and metabolic syndrome (MS). The prevalence of GBD is high in minority populations, such as Native and Mexican Americans. Ethnic differences, familial aggregation of GBD, and the identification of susceptibility loci for gallstone disease by use of animal models suggest genetic influences...
Topics
- Adult
- Aged
- Chromosomes, Human, Pair 1
- Gallbladder Diseases
- Genetic Predisposition to Disease
- Genome, Human
- Humans
- Intracellular Signaling Peptides and Proteins
- Lod Score