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Article

Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.

Scientific reports - 28 Jan 2019

Bustos Bernabé I, Pérez-Palma Eduardo, Buch Stephan, Azócar Lorena, Riveras Eleodoro, Ugarte Giorgia D, Toliat Mohammad, Nürnberg Peter, Lieb Wolfgang, Franke Andre, Hinz Sebastian, Burmeister Greta, von Schönfels Witigo, Schafmayer Clemens, Völzke Henry, Völker Uwe, Homuth Georg, Lerch Markus M, Santos José Luis, Puschel Klaus, Bambs Claudia, Roa Juan Carlos, Gutiérrez Rodrigo A, Hampe Jochen, De Ferrari Giancarlo V, Miquel Juan Francisco

Abstract excerpt

Latin Americans and Chilean Amerindians have the highest prevalence of gallstone disease (GSD) and gallbladder cancer (GBC) in the world. A handful of loci have been associated with GSD in populations of predominantly European ancestry, however, they only explain a small portion of the genetic component of the disease. Here, we performed a genome-wide association study (GWAS) for GSD in 1,095 admixed Chilean...

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Identifiers

PMID: 30692554
DOI: 10.1038/s41598-018-35852-z
PMCID: PMC6349870

Genes

TRAF3
ABCG8

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Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestryPMID 30692554Read ↗

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