Article
A German genome-wide linkage scan for type 2 diabetes supports the existence of a metabolic syndrome locus on chromosome 1p36.13 and a type 2 diabetes locus on chromosome 16p12.2.
Diabetologia - 1 Jul 2007
Hoffmann K, Mattheisen M, Dahm S, Nürnberg P, Roe C, Johnson J, Cox N J, Wichmann H E, Wienker T F, Schulze J, Schwarz P E, Lindner T H
Abstract excerpt
AIMS/HYPOTHESIS: The aim was to identify type 2 diabetes susceptibility regions in 250 German families. SUBJECTS AND METHODS: We conducted a genome-wide linkage scan using 439 short tandem repeat polymorphisms at an average resolution of 7.76 +/- 3.80 cM (Marshfield). In an affected-only-design (affected sib pairs), we performed nonparametric multipoint linkage analyses. Conditional analyses were applied where...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 16
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genome, Human
- Genomics
- Germany
- Humans
- Male
- Metabolic Syndrome