Article
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer research - 1 Jan 2006
Elstrodt Fons, Hollestelle Antoinette, Nagel Jord H A, Gorin Michael, Wasielewski Marijke, van den Ouweland Ans, Merajver Sofia D, Ethier Stephen P, Schutte Mieke
Abstract excerpt
Germ line mutations of the BRCA1 gene confer a high risk of breast cancer and ovarian cancer to female mutation carriers. The BRCA1 protein is involved in the regulation of DNA repair. How specific tumor-associated mutations affect the molecular function of BRCA1, however, awaits further elucidation. Cell lines that harbor BRCA1 gene mutations are invaluable tools for such functional studies. Up to now, the...
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