Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

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Article

Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

Cancer research - 1 Aug 1998

Tomlinson G E, Chen T T, Stastny V A, Virmani A K, Spillman M A, Tonk V, Blum J L, Schneider N R, Wistuba I I, Shay J W, Minna J D, Gazdar A F

Abstract excerpt

A tumor cell line, HCC1937, was established from a primary breast carcinoma from a 24-year-old patient with a germ-line BRCA1 mutation. A corresponding B-lymphoblastoid cell line was established from the patient's peripheral blood lymphocytes. BRCA1 analysis revealed that the tumor cell line is h...

Topics

Adult
Alleles
Breast Neoplasms
DNA, Neoplasm
Exons
Female
Genes, BRCA1
Germ-Line Mutation
Heterozygote
Humans
Karyotyping
Pedigree
Polymorphism, Single-Stranded Conformational
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9699648

Genes

BRCA1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9699648-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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