Article
Detection of EGFR-TK domain-activating mutations in NSCLC with generic PCR-based methods.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2015
Shahi Rajendra B, De Brakeleer Sylvia, De Grève Jacques, Geers Caroline, In't Veld Peter, Teugels Erik
Abstract excerpt
Somatic mutations in the epidermal growth factor receptor-tyrosine kinase (EGFR-TK) domain of non-small cell lung cancer (NSCLC) influence the responsiveness of these tumors to EGFR-TK inhibitors, indicating their usefulness as a predictive molecular marker. However, for mutation analysis, the amount of clinical material available from NSCLC patients is often very limited, suboptimally preserved, and composed of...
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