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Article

Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture.

Nucleic acids research - 1 Jul 1999

Giannini C D, Roth W K, Piiper A, Zeuzem S

Abstract excerpt

Due to their mode of action, ribozymes show antisense effects in addition to their specific cleavage activity. In the present study we investigated whether a hammerhead ribozyme is capable of cleaving mutated Ki-ras mRNA in a pancreatic carcinoma cell line and whether antisense effects contribute to the activity of the ribozyme. A 2[prime]-O-allyl modified hammerhead ribozyme was designed to cleave specifically...

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Share to Enzyme Activation
Share to Gene Expression Regulation
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Oligonucleotides, Antisense

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Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 10373591
DOI: 10.1093/nar/27.13.2737
PMCID: PMC148483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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