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Article

Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population.

Journal of leukocyte biology - 1 Mar 2006

Grimaldi Maria Paola, Candore Giuseppina, Vasto Sonya, Caruso Marco, Caimi Gregorio, Hoffmann Enrico, Colonna-Romano Giuseppina, Lio Domenico, Shinar Yael, Franceschi Claudio, Caruso Calogero

Abstract excerpt

A proinflammatory genotype seems to contribute significantly to the risk of developing coronary heart disease (CHD). Conversely, the susceptibility alleles to inflammatory disease should be infrequent in the genetic background favoring longevity. In fact, in a modern environment, attainment of longevity is facilitated by an anti-inflammatory status. To evaluate whether inflammatory alleles of pyrin, the gene...

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Identifiers

PMID: 16387839
DOI: 10.1189/jlb.0705416

Genes

MEFV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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