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Article

Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity.

Biogerontology - 1 Apr 2007

Listì Florinda, Candore Giuseppina, Grimaldi Maria Paola, Lio Domenico, Colonna-Romano Giuseppina, Orlando Valentina, Caruso Marco, Hoffmann Enrico, Paolisso Giuseppe, Franceschi Claudio, Caruso Calogero

Abstract excerpt

Genes involved in cardiovascular diseases (CVD) play an opposite role in human longevity. The alpha1-antitrypsin (AAT) is a serine-protease inhibitor required for the prevention of proteolytic tissue damage, by neutrophil elastase. The role of AAT in CVD has not been definitively assessed and its...

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PMID: 17048073
DOI: 10.1007/s10522-006-9041-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17048073-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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