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Article

Identifying selected regions from heterozygosity and divergence using a light-coverage genomic dataset from two human populations.

PloS one - 5 Mar 2008

Oleksyk Taras K, Zhao Kai, De La Vega Francisco M, Gilbert Dennis A, O'Brien Stephen J, Smith Michael W

Abstract excerpt

When a selective sweep occurs in the chromosomal region around a target gene in two populations that have recently separated, it produces three dramatic genomic consequences: 1) decreased multi-locus heterozygosity in the region; 2) elevated or diminished genetic divergence (F(ST)) of multiple polymorphic variants adjacent to the selected locus between the divergent populations, due to the alternative fixation of...

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Identifiers

PMID: 18320033
DOI: 10.1371/journal.pone.0001712
PMCID: PMC2248624

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