Identification of an ABC Transporter Required for Iron Acquisition and Virulence in<i>Mycobacterium tuberculosis</i>

Abstract excerpt

Iron availability affects the course of tuberculosis infection, and the ability to acquire this metal is known to be essential for replication of Mycobacterium tuberculosis in human macrophages. M. tuberculosis overcomes iron deficiency by producing siderophores. The relevance of siderophore synthesis for iron acquisition by M. tuberculosis has been demonstrated, but the molecules involved in iron uptake are...

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