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Article

MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.

Molecular microbiology - 1 Dec 2015

Pandey Ruchi, Russo Riccardo, Ghanny Saleena, Huang Xiaojuan, Helmann John, Rodriguez G Marcela

Abstract excerpt

The pathogenic mycobacterium Mycobacterium tuberculosis encodes two members of the DtxR/MntR family of metalloregulators, IdeR and SirR. IdeR represses gene expression in response to ferrous iron, and we here demonstrate that SirR (Rv2788), although also annotated as an iron-dependent repressor, functions instead as a manganese-dependent transcriptional repressor and is therefore renamed MntR. MntR regulates...

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Identifiers

PMID: 26337157
DOI: 10.1111/mmi.13207
PMCID: PMC5157835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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