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Article

ICOS deficiency in patients with common variable immunodeficiency.

Clinical immunology (Orlando, Fla.) - 1 Dec 2004

Salzer Ulrich, Maul-Pavicic Andrea, Cunningham-Rundles Charlotte, Urschel Simon, Belohradsky Bernd H, Litzman Jiri, Holm Are, Franco José Luis, Plebani Alessandro, Hammarstrom Lennart, Skrabl Andrea, Schwinger Wolfgang, Grimbacher Bodo

Abstract excerpt

Common variable immunodeficiency (CVID) is the most frequent clinically significant primary antibody deficiency in man, predisposing to recurrent bacterial infections. Recently, we showed that the homozygous loss of the inducible costimulator (ICOS) on activated T cells may result in an adult onset form of CVID with autosomal recessive inheritance (AR-CVID). We screened 181 sporadic CVID patients and 13 CVID...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inducible T-Cell Co-Stimulator Protein

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Source

Identifiers

PMID: 15507387
DOI: 10.1016/j.clim.2004.07.002

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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