Article
The marrow cell continuum: stochastic determinism.
Folia histochemica et cytobiologica - 1 Jan 2005
Quesenberry P, Abedi M, Dooner M, Colvin G, Sanchez-Guijo F Martin, Aliotta J, Pimentel J, Dooner G, Greer D, Demers D, Keaney P, Peterson A, Luo L, Foster B
Abstract excerpt
Traditional models of hematopoiesis have been hierarchical in nature. Over the past 10 years, we have developed data indicating that hematopoiesis is regulated in a continuum with deterministic and stochastic components. We have shown that the most primitive stem cells, as represented by lineage negative rhodamine(low) Hoechst(low) murine marrow cells are continuously or intermittently cycling as determined by in...
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