Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition.

The Journal of cell biology - 24 Nov 2003

Al-Bassam Jawdat, Cui Yujia, Klopfenstein Dieter, Carragher Bridget O, Vale Ronald D, Milligan Ronald A

Abstract excerpt

Caenhorhabditis elegans Unc104 kinesin transports synaptic vesicles at rapid velocities. Unc104 is primarily monomeric in solution, but recent motility studies suggest that it may dimerize when concentrated on membranes. Using cryo-electron microscopy, we observe two conformations of microtubule-bound Unc104: a monomeric state in which the two neck helices form an intramolecular, parallel coiled coil; and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Kinesins

Share to Molecular Motor Proteins

Share to Movement Disorders

Share to Nucleotides

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 14638858
DOI: 10.1083/jcb.200308020
PMCID: PMC2173678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition.PMID 14638858Read ↗

A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.Semantic proximity Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Structural model of microtubule dynamics inhibition by Kinesin-4 from the crystal structure of KLP-12 –tubulin complexSemantic proximity Read ↗

The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes.Semantic proximity Read ↗

Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cellsSemantic proximity Read ↗

The C. elegans unc-104 gene encodes a putative kinesin heavy chain-like protein.Semantic proximity Read ↗

Direct visualization of the movement of the monomeric axonal transport motor UNC-104 along neuronal processes in living Caenorhabditis elegans.Semantic proximity Read ↗

Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge.Semantic proximity Read ↗

Pathogenic KIF1A R350 Variants Disrupt A Conserved Kinesin-Tubulin Salt BridgeSemantic proximity Read ↗

Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.Semantic proximity Read ↗

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1Semantic proximity Read ↗

Allele-specific conformational rescue of KIF1A T99M by genetic suppressors in a C. elegans model of KIF1A-associated neurological disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.