Article
Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae.
Molecular cancer research : MCR - 1 Dec 2005
Chen Yijun, Feldman Douglas E, Deng Changchun, Brown James A, De Giacomo Anthony F, Gaw Allison F, Shi Gongyi, Le Quynh T, Brown J Martin, Koong Albert C
Abstract excerpt
Hypoxia activates all components of the unfolded protein response (UPR), a stress response initiated by the accumulation of unfolded proteins within the endoplasmic reticulum (ER). Our group and others have shown previously that the UPR, a hypoxia-inducible factor-independent signaling pathway, mediates cell survival during hypoxia and is required for tumor growth. Identifying new genes and pathways that are...
Topics
- Basic-Leucine Zipper Transcription Factors
- Calcium Signaling
- Cell Survival
- Dithiothreitol
- Endoplasmic Reticulum
- MAP Kinase Signaling System
- Membrane Glycoproteins
- Mercaptoethanol
- Mitogen-Activated Protein Kinases
- Mutation
- Open Reading Frames
- Protein Folding