Article
Applied glycoproteomics--approaches to study genetic-environmental collisions causing protein-losing enteropathy.
Biochimica et biophysica acta - 1 Apr 2006
Bode Lars, Freeze Hudson H
Abstract excerpt
Protein-losing enteropathy (PLE), the loss of plasma proteins through the intestine, is a life-threatening symptom associated with seemingly unrelated conditions including Crohn's disease, congenital disorder of glycosylation, or Fontan surgery to correct univentricular hearts. Emerging commonalities between these and other disorders led us to hypothesize that PLE develops when genetic insufficiencies collide...
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