Article
Long-term monitoring of genotypic and phenotypic resistance to T20 in treated patients infected with HIV-1.
Journal of medical virology - 1 Feb 2006
Pérez-Alvarez L, Carmona R, Ocampo A, Asorey A, Miralles C, Pérez de Castro S, Pinilla M, Contreras G, Taboada J A, Nájera R
Abstract excerpt
The aim of this study was to investigate the susceptibility to T20 and the dynamics of amino acid changes in HR1 and HR2 of gp41 of HIV-1 obtained from plasma, peripheral blood mononuclear cells (PBMC), and primary isolates (PI) in four highly antiretroviral-experienced patients. These patients received T20 plus an antiretroviral regimen and were followed-up over a period of 40-72 weeks. In one non-responder...
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