Article
Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.
The international journal of biochemistry & cell biology - 1 Apr 2013
Izumi Kazuki, Kawaji Kumi, Miyamoto Fusasko, Shimane Kazuki, Shimura Kazuya, Sakagami Yasuko, Hattori Toshio, Watanabe Kentaro, Oishi Shinya, Fujii Nobutaka, Matsuoka Masao, Kaku Mitsuo, Sarafianos Stefan G, Kodama Eiichi N
Abstract excerpt
T-20 (enfuvirtide) resistance is caused by the N43D primary resistance mutation at its presumed binding site at the N-terminal heptad repeat (N-HR) of gp41, accompanied by the S138A secondary mutation at the C-terminal HR of gp41 (C-HR). We have discovered that modifying T-20 to include S138A (T-...
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