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Mitotic phosphorylation of Tau/MAPT modulates cell cycle progression in prostate cancer cells

31 Mar 2023

Abstract excerpt

PURPOSE: Tau/MAPT (microtubule associated protein tau) protein is actively studied for the pathologic consequences of its aberrant proteostasis in central nervous system leading to neurodegenerative diseases. Besides its ability to generate insoluble toxic oligomers, Tau homeostasis has attracted attention for its involvement in the formation of the mitotic spindle. This evidence, in association with the...

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PMID: 37000265
DOI: 10.1007/s00432-023-04721-2

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