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GRB2 is a BECN1 interacting protein that regulates autophagy

5 Jan 2024

Abstract excerpt

GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class III PI3Kinase VPS34 activity. In ovo studies in a CAM (Chicken Chorioallantoic Membrane) model indicated that GRB2...

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PMID: 38182563
DOI: 10.1038/s41419-023-06387-7

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