Article
Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia
30 Sept 2022
Abstract excerpt
) gene was discovered based on its overexpression in human breast cancers. Subsequent work demonstrated that MUC1 is aberrantly expressed in cancers originating from other diverse organs, including skin and immune cells. These findings supported a role for MUC1 in the adaptation of barrier tissues to infection and environmental stress. Of fundamental importance for this evolutionary adaptation was inclusion of a...
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